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KMID : 0368820050440010025
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Journal of the Korean Neuropsychiatr Association
2005 Volume.44 No. 1 p.25 ~ p.31
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-1438A/G Polymorphism of the 5-HT2A Receptor Gene in Korean and Han Chinese Patients with Schizophrenia
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Yi Jang-Ho
Chung Joo-Ho
Li Guang-Zhe
Li Sheng-Fu
Wu Long-Ren
Chui Yong-Gen
Cho Ah-Rang
Chang Hwan-Il
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Abstract
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Objectives: The purpose of the present study was to investigate the association between -1438A/G polymorphism of 5-HT2A receptor gene and schizophrenia in Korean and Han Chinese population.
Methods: A sample of 184 Korean patients with schizophrenia and 96 Korean healthy normal controls and 96 Han Chinese patients with schizophrenia and 96 Han-Chinese healthy normal controls were genotyped for a single nucleotide polymorphism with in 5-HT2A receptor gene (promoter region, A-1438G) by Msp I Restriction Fragment Length Polymorphism (RFLP).
Results: There was no difference in allelic frequencies and genotype frequencies of -1438A/G polymorphism between Korean schizophrenics and controls (p=0.13) and Han Chinese schizophrenics and controls (p=0.40). Also, -1438A/G polymorphism did not show ethnical difference between Korean and Han Chinese controls. The Scale for the Assessment of Negative Symptoms (SANS) scores showed no significant differences between genotypes of -1438A/G polymorphism in both of Korean and Han Chinese schizophrenics.
Conclusion: These results suggest that -1438A/G polymorphism of the 5-HT2A receptor gene is not causally related to the development of schizophrenia in Korean and Han Chinese population, and there no ethnic difference between Korean and Han Chinese population.
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KEYWORD
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Schizophrenia, 5-HT2A receptor gene, -1438A/G polymorphism
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